The best and most correct answer among the choices provided by the question is the first choice "The hormone's signal is transduced through the cytoplasm of the target cell."
Water-soluble hormones include glycoproteins, catecholamines, and peptide hormones composed of polypeptides, e.g. thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone and insulin. These molecules are not lipid-soluble and therefore cannot diffuse through cell membranes.
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