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Average Speed = Total distance/ Total Time
total distance is 100mi
total time is (50mi / 33) + (50mi / 80)
total time is = 1.52 + 0.625 = 2.145
so average speed going to grandmothers house is 100mi / 2.145 hrs = 46.62 mph
on her return trip
x = V1 x t/2 + V2x t/2
100 = 33t/2 + 80t/2
100 = 113t/2
t = 100x2/113 = 1.7699hrs
average speed = 100mi/1.7699hrs = 56.60mph