jamie is not sure a new medication will work because it has not had a large test group. Is jamie being creative?
No, he is being skeptical.
In the situation above Jamie doubts because the test was done with a small sample. He thinks the results are uncertain because it is needed a big sample to avoid mistakes and icrease the reliability of the study. So, this leads to scepticism, which means doubt about the truth of something, this is what Jamie does in the situation, this is why he is being skeptical.