The Lysosome organelles have several dozen of enzymes in each one.
The word "Lysosome" comes from two Greek words. One, "Lysis" meaning destruction and two, "Soma" meaning body
There is really no way for a lysosome organelle to malfunction execpt if the cell starts eating to much and there are not enough lysosomes to digest all of the food. Which leeds up to the cell not being able to eat anymore.
