What are three different defects that could be responsible for malfunctioning lysosomes?

Select the three correct answers.

Aa defect in the synthesis of the glucose-6-phosphate dehydrogenase
Ba defect in the mannose-6-phosphate receptor in the Golgi apparatus
Ca defect in the releasing small molecules from digested materials into the cytosol
Da defect in a hydrolytic enzyme that breaks down polysaccharide
Ea defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases

F) a defect in the mannose-6-phosphate receptor in the mitochondria

Thank you for posting your question here. I believe the answer is the below:

B) a defect in the mannose-6-phosphate receptor in the Golgi apparatus
D) a defect in a hydrolytic enzyme that breaks down polysaccharide
F) a defect in the mannose-6-phosphate receptor in the mitochondria

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palipali964 palipali964 · Answer 2 · 2019-10-24T03:51:47-04:00

Answer:

B); D) and E)

Explanation:

B) a defect in the mannose-6-phosphate receptor in the Golgi apparatus.

Explanation: The mannose-6-phosphate receptors (MPR's) in the Golgi apparatus are essential for targeting the mannose-6-phosphate tagged lysosomal proteins to the lysosome.

D) a defect in a hydrolytic enzyme that breaks down polysaccharide.

Explanation: Lysosomes contain enzymes that hydrolyze polysaccharides, therefore any defects in these enzymes causes malfunctioning of the lysosome.

E) a defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases.

Explanation: In the Golgi apparatus lysosomal proteins are tagged with mannose-6-phosphate so that they are specifically transported to the lysosomes.